attomol^® Anti-Phospholipid-IgG/M Lineassay 3

The Anti-Phospholipid LINA 3, an attomol^® autoantibody Lineassay, is a manual strip test for the qualitative determination of IgG or IgM antibodies against phospholipids and lipid-binding proteins of the following 9 antigens in human serum, which can be used in the differential diagnosis of anti-phospholipid syndrome (APS):

• Annexin V
• Phosphatidylethanolamine 
• Prothrombin
• ß2-GP I
• Phosphatidylglycerol
• Cardiolipin
• Phosphatidylinositol
• Phosphatidic acid
• Phosphatidylserine

APS [Lim W., 2009, Hematology Am Soc Hematol Educ Program, 233-9] is one of the most common autoimmune diseases with predisposition to the female sex. Typical clinical symptoms are arterial and venous thrombosis, thrombocytophenia (reduction of platelet count) and habitual miscarriages [Roggenbuck et al., 2011, Elsevier, Autoimmunity Reviews 11, 821-826]. Anti-phospholipid syndrome contains specific antibodies against various phospholipids (cardiolipin, phosphatidic acid, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine, phosphatidylinositol) and lipid-binding proteins (ß2-GP I, Annexin V, Prothrombin) [Faricelli et al., 2008, Int J Immunopathol Pharmacol., 21(2):387-92; Jacob H.Rand et al., 2004, Blood, volume 104, number 9;  Monica Galli et al., 2003, Blood, volume 102, number 8]. These so-called anti-phospholipid antibodies lead to increased coagulability (hypercoagulability) of the blood and consequently to an increased incidence of thrombosis [Gibson GE et al., 1997,  J Am Acad Dermatol., 36(6 Pt 1):970-82].

• Test strips
• Buffer 10 x
• IgG-conjugate 21x
• IgM-conjugate 21x
• Substrate
• incubation trays
• interpretation template
• archive template
• instructions for use

You can find more informations about the Lineassay-Technology here.