attomol« Anti-Phospholipid-IgG/M Lineassay 3

REF 1176

20 reactions

Intended purpose

The Anti-Phospholipid LINA 3, an attomol« autoantibody Lineassay, is a manual strip test for the qualitative determination of IgG or IgM antibodies against phospholipids and lipid-binding proteins of the following 9 antigens in human serum, which can be used in the differential diagnosis of anti-phospholipid syndrome (APS):

  • Annexin V
  • Phosphatidylethanolamineá
  • Prothrombin
  • ▀2-GP I
  • Phosphatidylglycerol
  • Cardiolipin
  • Phosphatidylinositol
  • Phosphatidic acid
  • Phosphatidylserine
Field of application

APS [Lim W., 2009, Hematology Am Soc Hematol Educ Program, 233-9] is one of the most common autoimmune diseases with predisposition to the female sex. Typical clinical symptoms are arterial and venous thrombosis, thrombocytophenia (reduction of platelet count) and habitual miscarriages [Roggenbuck et al., 2011, Elsevier, Autoimmunity Reviews 11, 821-826]. Anti-phospholipid syndrome contains specific antibodies against various phospholipids (cardiolipin, phosphatidic acid, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylserine, phosphatidylinositol) and lipid-binding proteins (▀2-GP I, Annexin V, Prothrombin) [Faricelli et al., 2008, Int J Immunopathol Pharmacol., 21(2):387-92; Jacob H.Rand et al., 2004, Blood, volume 104, number 9;á Monica Galli et al., 2003, Blood, volume 102, number 8]. These so-called anti-phospholipid antibodies lead to increased coagulability (hypercoagulability) of the blood and consequently to an increased incidence of thrombosis [Gibson GE et al., 1997,á J Am Acad Dermatol., 36(6 Pt 1):970-82].

Kit content
Technology
  • Test strips
  • Buffer 10 x
  • IgG-conjugate 21x
  • IgM-conjugate 21x
  • Substrate
  • incubation trays
  • interpretation template
  • archive template
  • instructions for use

You can find more informations about the Lineassay-Technology here.

Short informations
Sample
Human serum
Devices
Rocking platform (40 U/min)
Duration
70 min
Reactions
20 strips
Annex

The Instructions for use and the Material safety data sheet can be accessed via the login area. This area is conserved for Attomol customers. Please log in with your customer number and the corresponding password. For further informations pleaseácontact us directly.